Scientific interests include immunology at the cellular and molecular level with a major focus on the plasma membrane organization of antigen-presenting cells. Tetraspanin proteins coordinate the spatial organization of specific immunoreceptors and signaling molecules into 'tetraspanin microdomains'. We discovered that tetraspanins are critically involved in immune cell function, including antigen presentation, proliferation and antibody production. The aim of our research is to unravel the molecular mechanisms that underlie tetraspanin microdomain function in immune cells in relation to the development of malignant disease.
Dr. Annemiek van Spriel is a tenured senior scientist at the Department of Tumor Immunology. She pursued a long-term Post-Doctoral Fellowship in the Leukocyte Membrane Laboratory of Ass. Prof. Mark Wright (Burnet Institute, Melbourne, Australia). In 2004, she joined the Tumor Immunology Department in the NCMLS where she obtained Grants from The Netherlands Organization for Scientific Research (NWO) and the Dutch Cancer Society (KWF) to establish her own research line that is focused on investigating tetraspanins in immune cells in relation to the development of cancer.
In 2012, she has been awarded the prestigious NWO-Vidi Grant for her work on tetraspanin proteins in the immune system.
National & International Personal Prizes & Awards
2007: Dutch Cancer Society (KWF) Grant 'Tetraspanin CD37 in the battle against cancer' (472,000 Euro).
2007: NWO-ALW Open Program Grant; 'The importance of tetraspanin proteins in membrane organization' (205,633 Euro).
2010: NCMLS Talent event PhD fellowship. 'Tetraspanin dynamics in the plasma membrane of living immune cells' (240,000 Euro). International PhD talent recruitment program in Molecular life sciences.
2011: Innovation Grant of the Dutch Kidney Foundation 'Tetraspanin CD37: a novel player in IgA nephropathy' (100,000 Euro).
2012: Vidi Grant (NWO) 800.000 Euro for her work on tetraspanin proteins in the immune system. 'Connecting the network: tetraspanin platforms in immune cell signaling'.
2012: NWO-MEERVOUD Grant Laureate
2013: Aspasia Grant (NWO) 100.000 Euro for her work on Tetraspanins in the immune system.
- The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival.
van Spriel AB, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, Linssen PC, Boezeman JB, Zuidscherwoude M, Reinieren-Beeren I, Cambi A, Mackay F, Tarlinton DM, Figdor CG, Wright MD.
- Dendritic cell science: more than 40 years of history
van Spriel AB, de Jong EC.
- The tetraspanin CD37 protects against glomerular IgA deposition and renal pathology.
Rops AL, Figdor CG, van der Schaaf A, Tamboer WP, Bakker MA, Berden JH, Dijkman HB, Steenbergen EJ, van der Vlag J, van Spriel AB.
- Fungal pattern-recognition receptors and Tetraspanins; Partners on antigen-presenting cells.
Figdor CG, van Spriel AB.
- The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.
van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, Raymakers RA, Loveland BE, Netea MG, Adema GJ, Wright MD, Figdor CG.
Keywords: (Auto)inflammatory Disorders / Cancer / Fungal Infections /
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